I tend to swap between qwerty and dvorak layouts, and the DDO client does very strange things with key layouts. Basically, it appears to have bound things to physical keys, so it reports the name of a given key if it can. I'm using an external keyboard with no number pad, but I had some stuff bound to num pad keys, and those show up as "Unknown +" or "Unknown -". Everything else is shuffled, too. So for instance, on the Dvorak layout, the fourth left-hand home-row key is u. So the shortcut for frame rate display is ctrl+u... Weird.
Also noticed: While client is up, everything else slows to a crawl, even though this is a quad-core machine running at maybe 15% load.