Tier 3 shroud hp items take a while to make, but tier 2 is fairly quick and gives you an extra 25hp (vs. 45 for the tier 3). Guild item slots can give up to 20hp, but I tend not to use them because of the 6h duration. Greater false life is readily available, and if you're a warforged you may want to try to obtain an unsuppressed quorforged docent (this is a nice consolidation item, bringing together +6con, superior false life, and toughness). Argonesson favor gives another 10hp if you have 150 favor (easy to get if you do all the GH quests on elite, but ofc dependent on you owning the pack).
Additionally, each epic level adds 10 + con mod + toughness mod hp, which in your case would be 20/level, so by 25 you'd have 472hp without any other additions in any case.
Having said all that, its still a good target to aim for 500hp minimum on a L25 artificer imo, which shouldn't be too difficult for most players.
Even mobile builds are hit by lag, or looking in the wrong direction, or momentary lapses of concentration. You're seriously telling me you can avoid disintegrate rays in the midst of heavy combat (with the associated lag etc) but you can't watch where you step when it comes to symbols?If I may retort in kind, in five lives my wizard was never killed by a disintegrate. This is the second key to my above point: we are speaking of mobile builds, able to avoid damage at literally the same time as doing damage. It is relatively easy to mitigate incoming rays this way, because rays only hit one spot. Symbols (and ball type spells) have a much larger radius of impact, and symbols specifically can lie in wait.
Hp is essentially a safety buffer. For a multi-tr toon, having a lower con or not having toughness or the related enhancements can be mitigated via past lives and gear. For a first life toon it can't, plus the level of familiarity with the game is likely to be lower. Therefore a large hp buffer is more helpful than a +2 to starting str, which will lose its impact by level 6-8 at the latest in any case.
I personaly never go below 16 for con on any toon..
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