Your character's alignment (among other things) determines what items you can or cannot use (sans UMD).
Lets say I have a Rogue with a high UMD. More than likely, I will be able to use anything I want to (via UMD). Most builds I see choose TN.
My question, is why? My thought, was that it was due to enemies doing damage to me based upon my being Good and/or Lawful/Chaotic thus being TN nerfs all of that.
It'd be a whole lot easier to just be NG (or even CG/LG) and not have to worry about UMD for items as much (those Pure Good weapons come to mind).
Mind you I'm currently level 14, and that's the highest I've ever been, so there's much of this game I do not yet know of. Any thoughts/comments/suggestions would be appreciated.