I hope it will help some.

Since UD16, i was unable to play.
The game was unable to go to character selection or crash as soon as i move mouse.
After a lot of try with no sucess, i made a new clean install of windows.
The game have worked until i have installed my cyborg gaming light.
After a few testing, the result was that the lighting pod itself that make ddo bug.
The simple fact that they are plug make ddo crash. Even if every processus to them have been killed.
Unplug it from usb and ddo work.
Plug it after ddo launched and it works!!!