Additional comments can be found in this thread: http://forums.ddo.com/showthread.php?t=381890
The new thrumming Sine-wave like effect on Fists of Light is really terrible - for me it's bad enough that it hits the right pitch to be headache inducing.
Please consider dropping this new sound effect.
Workaround: Reduce Combat Sound Effects audio channel down to 0.0, but this may preclude other Combat Sound Effects. Standard combat sounds such as weapon swipes/hits are not on this channel.