Loss of a feats, a bunch of healing amp, and yeah 4 DEX over STR compared to human.
FWIW . . . my ranger has ditched his Khopeshes, but only because I'm using CiTW weapons 99.9% of the time anyway so there wasn't much point in keeping the feat anymore.
Dual Nightmares on trash.
Dual Balizardes on Bosses
Dual Celestias handle all my DR-breaking needs and though they aren't quite as good as HBoGB Khopesehs I run content that needs Holy+Metal DR-breaking so rarely it doesn't matter if I took a small DPS hit.
The question now is splash versus pure because for the first time ever a Pure 20 Melee Ranger might be a good idea.