Favorite so far... The Proof is in the Poison

The reason? I recently joined a static group. My toon was the lowest level (3 at the time) in the group. It was the first time I ever did the quest and I didn't die. Came close, though.

Least favorite so far... that level 2 quest where you break up a gambling den (I forget the name)

The reason? The priest that used to give it was drinking in the Leaky Dingy tavern when he gave it to you. He went on about corruption in the city while getting sloshed in a bar. What a Hippocratic.